Synthesis Of Hybrid Molecules
In order to make high potency drug molecules one of the strategies would be to combine two bioactive molecules belonging to a particular therapeutic category. This approach has gained importance in the area of antibacterial agents where bacterial resistance is in prevalence. We have now extended this approach to other therapeutic categories such as anti-inflammatory and cytotoxic areas.
Naturally occurring triterpene molecules having anti-inflammatory are being combined covalently with other bioactive molecules. After making various hybrid molecules of different activities, we plan to subject to in-vitro experiments and also determine their mode of action.